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in a single embodiment, the CRISPR enzymes can be coupled into a sgRNA. In selected embodiments, the sgRNA targets a gene encoding a offered molecule as defined over. 262、细菌噬菌体可选自长尾噬菌体科(非限制性地比如以下属:cam病毒、lika病毒、r4病毒、acadian病毒、cooper病毒、pg1病毒、pipefish病毒、rose